通常在热退后出现皮疹和或黏膜疹等病变，但有些病例病变可能出现在前驱期或全身症状之前。皮疹可单个或多个，通常皮疹经过斑疹、丘疹、疱疹、脓疱和结痂阶段，不同阶段皮疹可同时存在。可伴明显痒感和疼痛。猴痘病变可累及口腔咽喉黏膜、肛门、直肠、生殖器、结膜和角膜等。结痂脱落后可遗留红斑或色素沉着，甚至瘢痕，瘢痕持续时间可长达数年。猴痘病程约2-4周。大多数病例为自限性疾病，症状会自行消失，也有重症和死亡发生，主要为儿童、孕妇和免疫低下人群。2022年，全球非地方性流行区感染患者的病死率约0.1%。与既往疫情（1970年至2021年）相比，2022年以来全球多国猴痘暴发疫情病例中，大多数临床表现较轻，有些没有前驱症状、皮疹少或没有皮疹，更多地出现生殖器、肛门及肛门直肠黏膜病变，可发生腮腺炎、龟头炎、尿潴留和直肠炎等，并发症有脑膜脑炎、广泛的坏死性病变，可累及多器官，死亡病例占报告病例约0.1%，主要为既往未得到治疗的艾滋病病毒感染者等免疫力低下人群。 

“zaiduoyinsutuidongxia，2020nianyilai，duozhongzhongyaocaichixuzhangjia。”beijingzhongyiyaodaxueyiyaoweishengfaxuejiaoshoudengyonggaosu《zhongguoxinwenzhoukan》，shouxian，yaopinzhiliangbiaozhuntigao，jianguanriquyange，fuhebiaozhundeyaopinbianshao，duizhongyaocaideyaoqiusuizhitigao，shidezhongyaocaijiageshuizhangchuangao。qici，guojiasuirangulibingtuijinzhongyaocaizhongzhijidijianshe，dantuijinguochengzhongnanmianhuiyouzhongzhihuzhuantouqitachanye，daozhibufenyaocaizhongzhijianshao，zhongzhichengbenshangzhang。zaizhe，shouqihouyingxiang，duozhongyaocaipubianjianchan，zhongcaoyaozhongzhimianjiyousuoweisuo，ruqingqiao、suanzaoren、baiziren、shayuanzi、baishudengyaocaiyinganhanyuhonglaojiaotichuxianjianchan。ciwai，zhongyaocaizhongzhijiagonggongyinanduzengjia、guojiaduijinkouzhongyaocaideguanzhidaozhiyixiezhongyaocaiyuanliaoquefa、laodongliliushidengyinsuyeshiyaojiapubianshangzhangdeyuanyin。“(“)在(zai)多(duo)因(yin)素(su)推(tui)动(dong)下(xia)，(，)2(2)02(2)0年(nian)以(yi)来(lai)，(，)多(duo)种(zhong)中(zhong)药(yao)材(cai)持(chi)续(xu)涨(zhang)价(jia)。(。)”(”)北(bei)京(jing)中(zhong)医(yi)药(yao)大(da)学(xue)医(yi)药(yao)卫(wei)生(sheng)法(fa)学(xue)教(jiao)授(shou)邓(deng)勇(yong)告(gao)诉(su)《(《)中(zhong)国(guo)新(xin)闻(wen)周(zhou)刊(kan)》(》)，(，)首(shou)先(xian)，(，)药(yao)品(pin)质(zhi)量(liang)标(biao)准(zhun)提(ti)高(gao)，(，)监(jian)管(guan)日(ri)趋(qu)严(yan)格(ge)，(，)符(fu)合(he)标(biao)准(zhun)的(de)药(yao)品(pin)变(bian)少(shao)，(，)对(dui)中(zhong)药(yao)材(cai)的(de)要(yao)求(qiu)随(sui)之(zhi)提(ti)高(gao)，(，)使(shi)得(de)中(zhong)药(yao)材(cai)价(jia)格(ge)水(shui)涨(zhang)船(chuan)高(gao)。(。)其(qi)次(ci)，(，)国(guo)家(jia)虽(sui)然(ran)鼓(gu)励(li)并(bing)推(tui)进(jin)中(zhong)药(yao)材(cai)种(zhong)植(zhi)基(ji)地(di)建(jian)设(she)，(，)但(dan)推(tui)进(jin)过(guo)程(cheng)中(zhong)难(nan)免(mian)会(hui)有(you)种(zhong)植(zhi)户(hu)转(zhuan)投(tou)其(qi)他(ta)产(chan)业(ye)，(，)导(dao)致(zhi)部(bu)分(fen)药(yao)材(cai)种(zhong)植(zhi)减(jian)少(shao)，(，)种(zhong)植(zhi)成(cheng)本(ben)上(shang)涨(zhang)。(。)再(zai)者(zhe)，(，)受(shou)气(qi)候(hou)影(ying)响(xiang)，(，)多(duo)种(zhong)药(yao)材(cai)普(pu)遍(bian)减(jian)产(chan)，(，)中(zhong)草(cao)药(yao)种(zhong)植(zhi)面(mian)积(ji)有(you)所(suo)萎(wei)缩(suo)，(，)如(ru)青(qing)翘(qiao)、(、)酸(suan)枣(zao)仁(ren)、(、)柏(bai)子(zi)仁(ren)、(、)沙(sha)苑(yuan)子(zi)、(、)白(bai)术(shu)等(deng)药(yao)材(cai)因(yin)干(gan)旱(han)与(yu)洪(hong)涝(lao)交(jiao)替(ti)出(chu)现(xian)减(jian)产(chan)。(。)此(ci)外(wai)，(，)中(zhong)药(yao)材(cai)种(zhong)植(zhi)加(jia)工(gong)工(gong)艺(yi)难(nan)度(du)增(zeng)加(jia)、(、)国(guo)家(jia)对(dui)进(jin)口(kou)中(zhong)药(yao)材(cai)的(de)管(guan)制(zhi)导(dao)致(zhi)一(yi)些(xie)中(zhong)药(yao)材(cai)原(yuan)料(liao)缺(que)乏(fa)、(、)劳(lao)动(dong)力(li)流(liu)失(shi)等(deng)因(yin)素(su)也(ye)是(shi)药(yao)价(jia)普(pu)遍(bian)上(shang)涨(zhang)的(de)原(yuan)因(yin)。(。)